منابع مشابه
R2 Imaging of Ferritin Iron in Thalassemic Patients Off and On Iron-Chelation Therapy
D. Kim, J. H. Jensen, C. L. Tosti, E. X. Wu, S. S. Sheth, T. R. Brown, and G. M. Brittenham Center for Biomedical Imaging and Radiology, NYU Langone Medical Center, New York, NY, United States, Bioengineering, Columbia University, New York, NY, United States, Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam, Hong Kong, Pediatrics and Medicine, Columbia University Col...
متن کاملCatechol releases iron(III) from ferritin by direct chelation without iron(II) production.
It has been traditionally considered that catechols release iron from ferritin by reduction to iron(II), which diffuses through the ferritin channels into the intracellular milieu where it participates in the Fenton reaction, producing highly toxic hydroxyl radicals. However, in the present work we have proved that the mechanism of the release of iron from ferritin by catechol does not take pla...
متن کاملChromosome-damaging activity of ferritin and its relation to chelation and reduction of iron.
Ferritin from horse spleen was found to cause severe chromosome aberrations in cultured Chinese hamster ovary cells. Ferritin at 15 to 170 microgram/ml was clastogenic and at higher doses was cytotoxic. At comparable concentrations of protein or iron, neither apoferritin nor complexed iron was clastogenic. Sulfhydryl compounds glutathione and cysteine reduced the cytotoxic and clastogenic activ...
متن کاملIron release and uptake by plant ferritin: effects of pH, reduction and chelation.
Ferritins are iron-storage proteins that accumulate in plastids during seed formation, and also in leaves during senescence or iron overload. Iron release from ferritins occurs during growth of seedlings and greening of plastids. Depending on the concentration of the reducing agent ascorbate, either an overall iron release or uptake by ferritins from iron(III) citrate may occur. We have designe...
متن کاملIRON METABOLISM Iron overload and chelation
Iron is one of the most common elements in nature. As a transition metal it is very efficient in electron transport and redox reactions. The proteins and enzymes in which iron is an essential component play a key role in respiration, energy production, detoxification of harmful oxygen species and cell replication. Despite the abundance of iron in nature, the solubility of its stable ferric form...
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ژورنال
عنوان ژورنال: Autophagy
سال: 2010
ISSN: 1554-8627,1554-8635
DOI: 10.4161/auto.6.1.10587